**Offer Code:**OE202512/0505 **Offer Type:**Open Competitive Procedure **Status:**Active **Organizational Level:**Ministry of Education, Science and Innovation **Agency/Service:**University of Coimbra **Employment Contract:**Fixed-term contract for a definite period (CTFP) **Duration:**35 months **Work Regime:**Unreviewed Career Path **Career:**Researcher **Category:**Any **Complexity Level:**0 **Remuneration:**€2,351.53 — Remuneration Level 33 of the TRU **Monthly Supplement:**€0.00 **Job Description:**The candidate will join a research project aiming to modulate striatal Fyn levels in the context of Huntington’s disease (HD) to: 1) restore striatal function and early motor and non-motor behavioral alterations; 2) investigate interactions between Fyn and mitochondrial proteins, and their role in glutamatergic synapse function and morphology. The candidate will plan, conduct, and analyze experiments using appropriate methodologies and document all project-related activities. Mandatory requirement: proven experience in studies of mitochondrial dysfunction and oxidative stress in glutamatergic synapses, including mitochondrial morphology and dynamics in cellular/animal models of neurodegenerative diseases. Preferred qualifications include expertise in transcardiac perfusion, preparation and analysis of brain samples for transmission electron microscopy (TEM), isolation of brain mitochondria and synaptosomes, and primary cultures of cortical and striatal neurons. **Workplace** **Number of Positions** **Address** **Locality** **Postal Code** **District** **Municipality** University of Coimbra 1 Paço das Escolas Coimbra 3004531 COIMBRA Coimbra Coimbra **Total Number of Positions:**1 **Quota for Persons with Disabilities:**0