Researcher

Description

Job Summary: The candidate will join a research project aimed at modulating striatal Fyn levels in the context of Huntington's disease. Key Highlights: 1. Integrate a research project on neurodegenerative disease 2. Plan, conduct, and analyze experiments using appropriate methodologies 3. Experience in studies of mitochondrial dysfunction and oxidative stress **Offer Code:**OE202605/0682 **Offer Type:**Open Competitive Procedure **Status:**Active **Organizational Level:**Ministry of Education, Science and Innovation **Department/Service:**University of Coimbra **Employment Contract:**Fixed-term public employment contract (CTFP) **Duration:**36 months **Work Regime:**Non-reviewed Career Pathways **Career:**Researcher **Category:**Any **Complexity Level:**0 **Remuneration:**2\.408,11 € (Level 33 of the 2026 Single Remuneration Table\) **Monthly Supplement:**0.00 EUR **Job Description:** The candidate will join a research project whose objective is to modulate striatal Fyn levels in the context of Huntington's disease (HD), with the following aims: 1\) Restore striatal function and motor and/or non-motor behavioral alterations; 2\) Investigate interactions between Fyn and mitochondria, and their role in the function and morphology of glutamatergic synapses. The candidate will plan, conduct, and analyze experiments using appropriate methodologies and document all project activities. The candidate must demonstrate proven experience in studies of mitochondrial dysfunction and oxidative stress, and in the analysis of glutamatergic synapses, including mitochondrial morphology and dynamics in cellular and animal models of neurodegenerative diseases. Knowledge of transcardiac perfusion, preparation and analysis of brain samples for transmission electron microscopy (TEM), isolation of brain mitochondria and synaptosomes, and primary cultures of cortical and striatal neurons is considered an asset. **Workplace** **Number of Positions** **Address** **Locality** **Postal Code** **District** **Municipality** University of Coimbra 1 Paço das Escolas Coimbra 3004531 COIMBRA Coimbra Coimbra **Total Number of Positions:**1 **Quota for Persons with Disabilities:**0